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Version: 16.10e (Release date: 2016-10-31)
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pan FGFR Kinase Inhibitor BGJ398 (Code C88302)

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Terms & Properties

Preferred Name: pan FGFR Kinase Inhibitor BGJ398

Definition: An orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. pan FGFR kinase inhibitor BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival.

Display Name: pan FGFR Kinase Inhibitor BGJ398

Label: pan FGFR Kinase Inhibitor BGJ398

NCI Thesaurus Code: C88302 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2981819  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BGJ398
pan FGFR Kinase Inhibitor BGJ398

External Source Codes: 
ChEBI ID CHEBI:63451 (see ChEBI info)
PDQ Closed Trial Search ID 659161
PDQ Open Trial Search ID 659161 (check for NCI PDQ open clinical trial info)
UMLS CUI C2981819

Other Properties:
Name Value (qualifiers indented underneath)
code C88302
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88302

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