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Version: 16.11d (Release date: 2016-11-28)
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Dalantercept (Code C88296)

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Terms & Properties

Preferred Name: Dalantercept

Definition: A soluble fusion protein containing the extracellular domain of activin receptor-like kinase-1 (ALK1) fused to a human Fc domain (ALK1-Fc fusion protein), with potential antiangiogenic and antineoplastic activities. Upon administration, dalantercept binds to various ALK1 ligands, preventing activation of tumor cell ALK1 receptors and so inhibiting the ALK1 signaling pathway; growth factor-induced angiogenesis is thus inhibited, which may result in the inhibition of tumor cell proliferation and tumor cell death. ALK1 is a type I cell surface receptor with serine/threonine kinase activity that mediates signaling by members of the transforming growth factor-beta (TGFbeta) superfamily and plays a key role in angiogenesis; ligands for this receptor include TGFbeta1 and TGFbeta2. The Fc moiety of this fusion protein mediates clearance of ligand-fusion protein complexes by the reticuloendothelial system (RES).

Display Name: Dalantercept

Label: Dalantercept

NCI Thesaurus Code: C88296 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3537264  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ACE-041
Activin Receptor-like Kinase 1 Inhibitor ACE-041
ALK1-Fc Fusion Protein ACE-041
Dalantercept
DALANTERCEPT

External Source Codes: 
CAS Registry Number 1186210-24-1 (see NLM ChemIDplus info)
FDA UNII Code EGC16R10V0
PDQ Closed Trial Search ID 658276
PDQ Open Trial Search ID 658276 (check for NCI PDQ open clinical trial info)
UMLS CUI C3537264

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C3206H4960N904O976S38
code C88296
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88296

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