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Version: 17.12d (Release date: 2017-12-26)
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Dalantercept (Code C88296)

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Terms & Properties

Preferred Name: Dalantercept

Definition: A soluble fusion protein containing the extracellular domain of activin receptor-like kinase-1 (ALK1) fused to a human Fc domain (ALK1-Fc fusion protein), with potential antiangiogenic and antineoplastic activities. Upon administration, dalantercept binds to various ALK1 ligands, preventing activation of tumor cell ALK1 receptors and so inhibiting the ALK1 signaling pathway; growth factor-induced angiogenesis is thus inhibited, which may result in the inhibition of tumor cell proliferation and tumor cell death. ALK1 is a type I cell surface receptor with serine/threonine kinase activity that mediates signaling by members of the transforming growth factor-beta (TGFbeta) superfamily and plays a key role in angiogenesis; ligands for this receptor include TGFbeta1 and TGFbeta2. The Fc moiety of this fusion protein mediates clearance of ligand-fusion protein complexes by the reticuloendothelial system (RES).

Display Name: Dalantercept

Label: Dalantercept

NCI Thesaurus Code: C88296 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3537264  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Activin Receptor-like Kinase 1 Inhibitor ACE-041
ALK1-Fc Fusion Protein ACE-041

External Source Codes: 
CAS Registry Number 1186210-24-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 658276
PDQ Open Trial Search ID 658276 (check for NCI PDQ open clinical trial info)
UMLS CUI C3537264

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C3206H4960N904O976S38
code C88296
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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