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Version: 17.12d (Release date: 2017-12-26)
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Birinapant (Code C88295)

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Terms & Properties

Preferred Name: Birinapant

Definition: A synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, birinapant selectively binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 (cIAP1) and 2 (cIAP2), with a greater effect on cIAP1 than cIAP2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells and inactivate the nuclear factor-kappa B (NF-kB)-mediated survival pathway. IAPs are overexpressed by many cancer cell types. They are able to suppress apoptosis by binding to, via their baculoviral lAP repeat (BIR) domains, and inhibiting active caspases-3, -7 and -9. IAP overexpression promotes both cancer cell survival and chemotherapy resistance.

Display Name: Birinapant

Label: Birinapant

NCI Thesaurus Code: C88295 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3658709  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Propanamide, N,N'-[(6,6'-difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-,(2S,2'S)-

External Source Codes: 
CAS Registry Number 1260251-31-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 657946
PDQ Open Trial Search ID 657946 (check for NCI PDQ open clinical trial info)
UMLS CUI C3658709

Other Properties:
     Name Value (qualifiers indented underneath)
code C88295
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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