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Version: 17.06d (Release date: 2017-06-26)
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Indium In 111 Capromab Pendetide (Code C88292)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Indium In 111 Capromab Pendetide

Definition: A radioimmunoconjugate consisting of the murine IgG1 kappa monoclonal antibody capromab (7E11-C5.3), conjugated to the linker-chelator glycyl-tyrosyl-(N,-diethylenetriaminepentaacetic acid)-lysine hydrochloride (GYK-DTPA-HCl) and labeled with radioisotope indium In 111, with ligand-binding and gamma-emitting activities. Upon intravenous administration, indium In 111-capromab pendetide binds to a cytoplasmic epitope of human prostate specific membrane antigen (PSMA) expressed on prostate tumor cell surfaces via its capromab moiety and, upon internalization, allows radioimmunolocalization with gamma scintigraphy. PSMA is a cell surface glycoprotein abundantly expressed by prostate epithelium and is typically overexpressed by prostate cancer cells.

Display Name: Indium In 111 Capromab Pendetide

Label: Indium In 111 Capromab Pendetide

NCI Thesaurus Code: C88292 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2959379  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
111-In Capromab Pendetide
Indium In 111 Capromab Pendetide

External Source Codes: 
PDQ Closed Trial Search ID 657687
PDQ Open Trial Search ID 657687 (check for NCI PDQ open clinical trial info)
UMLS CUI C2959379

Other Properties:
     Name Value (qualifiers indented underneath)
code C88292
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88292

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