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Version: 17.06d (Release date: 2017-06-26)
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EGFR Inhibitor PF-00299804 (Code C88291)

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Terms & Properties

Concept Status: Retired Concept  (See:  Dacomitinib )

Preferred Name: EGFR Inhibitor PF-00299804

Definition: An orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. EGFR inhibitor PF-00299804 specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types.

Label: EGFR Inhibitor PF-00299804

NCI Thesaurus Code: C88291 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL415038  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EGFR Inhibitor PF-00299804
PF-00299804

External Source Codes: 
NCI META CUI CL415038

Other Properties:
     Name Value (qualifiers indented underneath)
code C88291
Concept_Status Retired_Concept
deprecated true
DesignNote Thu Sep 02 15:17:02 EDT 2010 - See 'PF-00299804'
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88291

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