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Version: 17.06d (Release date: 2017-06-26)
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Pegylated Recombinant Human Arginase I BCT-100 (Code C88286)

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Terms & Properties

Preferred Name: Pegylated Recombinant Human Arginase I BCT-100

Definition: A recombinant human arginase I (liver arginase) covalently attached, via a succinamide propionic acid (SPA) linker, to a polyethylene glycol (PEG) of molecular weight 5,000 [rhArg-peg(5,000mw)] with potential antineoplastic activity. Upon intravenous administration of pegylated recombinant human arginase I BCT-100, arginase metabolizes the amino acid arginine to ornithine and urea, depleting intracellular arginine, which may inhibit proliferation of cells that are auxotrophic for arginine such as hepatocellular carcinoma (HCC) cells. This agent may also work synergistically with various cytotoxic agents.

Label: Pegylated Recombinant Human Arginase I BCT-100

NCI Thesaurus Code: C88286 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413535  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BCT-100
Pegylated Recombinant Human Arginase I BCT-100
rhArgIpeg5000

External Source Codes: 
PDQ Closed Trial Search ID 657226
PDQ Open Trial Search ID 657226 (check for NCI PDQ open clinical trial info)
NCI META CUI CL413535

Other Properties:
     Name Value (qualifiers indented underneath)
code C88286
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88286

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