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Version: 17.06d (Release date: 2017-06-26)
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Iodine I-124 FIAU (Code C88284)

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Terms & Properties

Preferred Name: Iodine I-124 FIAU

Definition: A radioconjugate containing the nucleoside analog 2'-fluoro-2'-deoxy-1beta-D-arabinofuranosyl-5-iodouracil (FIAU) labeled with the radioisotope iodine I 124 with positron-emitting activity. Chemotherapeutic agents such as bortezomib may induce viral thymidine kinase expression in EBV- and Kaposi's sarcoma herpesvirus (KSHV)-associated tumors. Subsequent to chemotherapy induction of viral TK in these tumors, administered iodine I 124 FIAU is phosphorylated by expressed viral TK, becoming selectively trapped within TK-expressing tumor cells; these cells can then be visualized with positron emission tomography (PET). Viral TK is either not expressed or is expressed at very low levels in EBV- and Kaposi's sarcoma herpesvirus (KSHV)-associated tumors and may be activated by certain chemotherapeutic agents.

Display Name: Iodine I-124 FIAU

Label: Iodine I-124 FIAU

NCI Thesaurus Code: C88284 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413534  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
124I-2-Fluoro-2-deoxy-5-[124I]iodo-1beta-d-arabinofuranosyluracil
124I-FIAU
Iodine I-124 FIAU

External Source Codes: 
PDQ Closed Trial Search ID 656874
PDQ Open Trial Search ID 656874 (check for NCI PDQ open clinical trial info)
NCI META CUI CL413534

Other Properties:
     Name Value (qualifiers indented underneath)
code C88284
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88284

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