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Version: 17.08d (Release date: 2017-08-28)
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Necitumumab (Code C88281)

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Terms & Properties

Preferred Name: Necitumumab

Definition: A fully human IgG1 monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Necitumumab binds to and blocks the ligand binding site of EGFR, thereby preventing the activation and subsequent dimerization of the receptor. This may lead to an inhibition of EGFR-dependent downstream pathways and so inhibition of EGFR-dependent tumor cell proliferation and metastasis. EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of various tumor cell types.

Display Name: Necitumumab

Label: Necitumumab

NCI Thesaurus Code: C88281 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2352806  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-Epidermal Growth Factor Receptor Monoclonal Antibody IMC-11F8
IMC-11F8
Immunoglobulin G1, Anti-(Human Epidermal Growth Factor Receptor (Receptor Tyrosine-Protein Kinase ErbB-1, EC 2.7.10.1)); Human Monoclonal IMC-11F8 Gamma1 Heavy Chain (224-214')-Disulfide with Human Monoclonal IMC-11F8 Kappa Light Chain, Dimer (230- 230'':233-233'')-Bisdisulfide
Necitumumab
NECITUMUMAB
Portrazza

External Source Codes: 
CAS Registry Number 906805-06-9 (see NLM ChemIDplus info)
FDA UNII Code 2BT4C47RUI
PDQ Closed Trial Search ID 656651
PDQ Open Trial Search ID 656651 (check for NCI PDQ open clinical trial info)
UMLS CUI C2352806

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For metastatic squamous non-small cell lung cancer (NSCLC)
code C88281
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88281

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