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Version: 17.06d (Release date: 2017-06-26)
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Lutetium Lu 177-Edotreotide (Code C88277)

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Terms & Properties

Preferred Name: Lutetium Lu 177-Edotreotide

Definition: A radioconjugate consisting of the somatostatin analogue edotreotide labeled with lutetium Lu 177 with potential antineoplastic activities. Lutetium Lu 177-edotreotide binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. Edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide (Tyr3-octreotide or TOC) and chelated by the bifunctional, macrocyclic chelating agent dodecanetetraacetic acid (DOTA).

Display Name: Lutetium Lu 177-Edotreotide

Label: Lutetium Lu 177-Edotreotide

NCI Thesaurus Code: C88277 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412466  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Lutetium Lu 177-Edotreotide
Lutetium Lu 177 DOTA-Tyr3-octreotide

External Source Codes: 
PDQ Closed Trial Search ID 656307
PDQ Open Trial Search ID 656307 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 18448552 (see PubMed Primary Reference info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C88277
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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