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Version: 17.12d (Release date: 2017-12-26)
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Technetium Tc-99m Demobesin-4 (Code C88276)

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Terms & Properties

Preferred Name: Technetium Tc-99m Demobesin-4

Definition: A radioconjugate composed of the synthetic bombesin (BB) analog demobesin-4 bound to the radioisotope technetium Tc 99m with receptor ligand and gamma-emitting radioisotope activities. Upon intravenous administration, demobesin-4 selectively binds to the gastrin-releasing peptide receptor (GRPR) expressed on the surfaces of various tumor cell types; upon internalization, tumor cells expressing GRPRs bound to technetium Tc 99m can then be visualized using scintigraphy. GRPR, a bombesin receptor subtype, is frequently overexpressed on the surface of tumor cells such as prostate and breast cancer cells. Demobesin-4 was developed for technetium Tc 99m imaging of GRPR-expressing tumor cells.

NCI-GLOSS Definition: A substance being studied as a way to find certain types of cancer. It contains a radioactive substance called technetium linked to another substance called demobesin. Demobesin binds to the receptor for bombesin (a substance that is found at higher-than-normal levels on some types of cancer cells). Technetium Tc 99m demobsin-4 collects in cancer cells and a machine is used to find where the cancer cells are in the body. It is a type of radiopharmaceutical and a type of radioimaging agent.

Label: Technetium Tc-99m Demobesin-4

NCI Thesaurus Code: C88276 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412465  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
99mTc Demobesin-4
technetium Tc 99m demobesin-4
Technetium Tc-99m Demobesin-4

External Source Codes: 
PDQ Closed Trial Search ID 656155
PDQ Open Trial Search ID 656155 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C88276
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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