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Version: 16.10e (Release date: 2016-10-31)
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Smac Mimetic GDC-0152 (Code C88274)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Smac Mimetic GDC-0152

Definition: A second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Smac, the endogenous IAP antagonist, relies on its N-terminal four amino-acid motif for binding to IAPs.

Display Name: Smac Mimetic GDC-0152

Label: Smac Mimetic GDC-0152

NCI Thesaurus Code: C88274 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2981796  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GDC-0152
IAP Antagonist GDC-0152
Smac Mimetic GDC-0152

External Source Codes: 
PDQ Closed Trial Search ID 655953
PDQ Open Trial Search ID 655953 (check for NCI PDQ open clinical trial info)
UMLS CUI C2981796

Other Properties:
Name Value (qualifiers indented underneath)
code C88274
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88274

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