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Version: 16.11d (Release date: 2016-11-28)
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PI3K Inhibitor GSK2126458 (Code C88270)

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Terms & Properties

Preferred Name: PI3K Inhibitor GSK2126458

Definition: A small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity. PI3K inhibitor GSK2126458 binds to and inhibits PI3K in the PI3K/mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability and inducing apoptotic cell death. Bax is a member of the proapoptotic Bcl2 family of proteins. PI3K, often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.

Display Name: PI3K Inhibitor GSK2126458

Label: PI3K Inhibitor GSK2126458

NCI Thesaurus Code: C88270 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2981793  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GSK2126458
PI3K Inhibitor GSK2126458

External Source Codes: 
PDQ Closed Trial Search ID 655580
PDQ Open Trial Search ID 655580 (check for NCI PDQ open clinical trial info)
UMLS CUI C2981793

Other Properties:
Name Value (qualifiers indented underneath)
code C88270
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88270

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