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Version: 17.06d (Release date: 2017-06-26)
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VEGFR Inhibitor KRN951 (Code C88267)

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Terms & Properties

Preferred Name: VEGFR Inhibitor KRN951

Definition: An orally bioavailable quinoline-urea derivative inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1 and 2 with potential antiangiogenesis and antineoplastic activities. VEGFR inhibitor KRN951 inhibits VEGF-induced phosphorylation of VEGFRs 1 and 2, which may result in inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and tumor cell death. Expression of VEGFRs may be upregulated in a variety of tumor cell types.

Label: VEGFR Inhibitor KRN951

NCI Thesaurus Code: C88267 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2976524  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N'-(5-methyl-3-isoxazolyl) Urea Hydrochloride Monohydrate
VEGFR Inhibitor KRN951

External Source Codes: 
PDQ Closed Trial Search ID 655018
PDQ Open Trial Search ID 655018 (check for NCI PDQ open clinical trial info)
UMLS CUI C2976524

Other Properties:
     Name Value (qualifiers indented underneath)
code C88267
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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