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Version: 17.06d (Release date: 2017-06-26)
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CD19CAR-CD3zeta-expressing Autologous T lymphocytes (Code C88266)

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Terms & Properties

Preferred Name: CD19CAR-CD3zeta-expressing Autologous T lymphocytes

Definition: Autologous T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-expressing autologous T-lymphocytes are directed to CD19-expressing tumor cells, thereby inducing a selective toxicity only in these tumor cells. The CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3-zeta (or CD247) is a transmembrane signaling adaptor polypeptide that regulates the assembly of complete T-cell receptor complexes and their expression on the cell surface.

Label: CD19CAR-CD3zeta-expressing Autologous T lymphocytes

NCI Thesaurus Code: C88266 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416075  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Autologous CART-19:TCR Cells
CD19CAR-CD3zeta-expressing Autologous T lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 736185
PDQ Open Trial Search ID 736185 (check for NCI PDQ open clinical trial info)
NCI META CUI CL416075

Other Properties:
     Name Value (qualifiers indented underneath)
code C88266
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88266

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