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Version: 17.06d (Release date: 2017-06-26)
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C-VISA BikDD:Liposome (Code C88264)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: C-VISA BikDD:Liposome

Definition: A formulation composed of DOTAP:cholesterol liposome nanoparticles complexed with the plasmid C-VISA BiKDD, with potential antineoplastic activity. C-VISA BikDD: liposome consists of a pancreatic-cancer-specific expression vector VISA (VP16-GAL4-WPRE integrated systemic amplifier) and a pancreatic-cancer-specific promoter CCKAR (cholecystokinin type A receptor) (CCKAR-VISA or C-VISA) which drives expression of the gene BikDD, a mutant form of the potent proapoptotic gene Bik (Bcl-2 interacting killer). Upon administration and transduction into pancreatic tumor cells, expression of BikDD by C-VISA BikDD:liposome may induce pancreatic tumor cell apoptosis and suppress pancreatic tumor cell proliferation. BikDD binds with greater affinity to anti-apoptotic proteins bcl-2, bcl-xl, bcl-w and Mcl-1 and is more potent than wild-type Bik. DOTAP:cholesterol liposome is composed of cationic lipid dioleoyl-trimethylammonium propane (DOTAP) and cholesterol at molar ratio of 1:1.

Display Name: C-VISA BikDD:Liposome

Label: C-VISA BikDD:Liposome

NCI Thesaurus Code: C88264 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412442  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
C-VISA BikDD:Liposome
C-VISA BikDD Plasmid: DOTAP:Cholesterol Liposome-Based Nanoparticle

External Source Codes: 
PDQ Closed Trial Search ID 654631
PDQ Open Trial Search ID 654631 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412442

Other Properties:
     Name Value (qualifiers indented underneath)
code C88264
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88264

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