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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Ad5.SSTR/TK.RGD (Code C88261)

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Terms & Properties

Preferred Name: Ad5.SSTR/TK.RGD

Definition: An RGD-4C-modified, infectivity-enhanced, bicistronic type 5 adenovirus expressing herpes simplex virus thymidine kinase (HSV-tk) gene, a therapeutic suicide gene, and the somatostatin receptor type 2 (SSTR2) gene with potential antineoplastic activity. Modification with the double cyclic peptide RGD-4C allows the virus to bind to cellular integrins, frequently expressed on the surfaces of ovarian cancer cells, instead of the coxsackie and adenovirus (CAR) receptor, which is often nonfunctional in ovarian cancer cells. Upon intratumoral administration, Ad5.SSTR/TK.RGD transfects tumor cells and expresses the HSV-tk gene. After subsequent administration of a synthetic acyclic guanosine analogue prodrug like ganciclovir (GCV), expressed HSV-tk phosphorylates and activates the prodrug, which may result in inhibition of DNA synthesis and apoptosis in HSV-tk-expressing cancer cells. Additionally, as a bystander effect, adjacent non-transfected cells may be killed by the activated antiviral drug. SSTR2 expression allows imaging of gene transfer into tumor cells using a radiolabeled somatostatin analogue.

Display Name: Ad5.SSTR/TK.RGD

Label: Ad5.SSTR/TK.RGD

NCI Thesaurus Code: C88261 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412438  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
RGD-Modified Adenoviral Vector Encoding SSTR/TK

External Source Codes: 
PDQ Closed Trial Search ID 654580
PDQ Open Trial Search ID 654580 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C88261
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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