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Version: 17.06d (Release date: 2017-06-26)
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Resiquimod Topical Gel (Code C88259)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Resiquimod Topical Gel

Definition: A topical gel containing the Toll-like receptor (TLR) agonist resiquimod, an imidazoquinolinamine and with potential immunomodulating activity. Resiquimod binds toTLR7 and 8, mainly on dendritic cells, macrophages, and B-lymphocytes, and activates the TLR signaling pathway, resulting in the induction of the nuclear translocation of transcription activator NF-kB and activation of other transcription factors; subsequently, gene expression increases and the production of cytokines increases, especially interferon-alpha (INF-a), resulting in the enhancement of T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate epidermal Langerhans cells, leading to an enhanced activation of T-lymphocytes.

Display Name: Resiquimod Topical Gel

Label: Resiquimod Topical Gel

NCI Thesaurus Code: C88259 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412435  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
R848 Gel
Resiquimod Topical Gel

External Source Codes: 
PDQ Closed Trial Search ID 654328
PDQ Open Trial Search ID 654328 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412435

Other Properties:
     Name Value (qualifiers indented underneath)
code C88259
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C88259

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