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Version: 16.10e (Release date: 2016-10-31)
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Picropodophyllin (Code C87736)

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Terms & Properties

Preferred Name: Picropodophyllin

Definition: A cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells.

Label: Picropodophyllin

NCI Thesaurus Code: C87736 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0961664  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AXL1717
Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-,(5R-(5-alpha,5a-alpha,8a-alpha,9-alpha))-
PICROPODOPHYLLIN
Picropodophyllin
Picropodophyllotoxin

External Source Codes: 
CAS Registry Number 477-47-4 (see NLM ChemIDplus info)
FDA UNII Code 0F35AOI227
NSC Code 36407 (see NCI DTP info)
PDQ Closed Trial Search ID 729917
PDQ Open Trial Search ID 729917 (check for NCI PDQ open clinical trial info)
UMLS CUI C0961664

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C22H22O8
code C87736
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C87736

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