skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Telavancin Hydrochloride (Code C87636)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Telavancin Hydrochloride

Definition: The hydrochloride salt form of telavancin, a lipoglycopeptide and a semisynthetic derivative of vancomycin with antibacterial activity against gram-positive bacteria. Like vancomycin, telavancin binds tightly to the D-alanyl-D-alanine residue of cell wall precursors, thereby interfering with bacterial cell wall synthesis. In addition, the lipophilic moiety of telavancin may interact with the lipid bilayer in the bacterial cell membrane, thereby compromising the integrity of cell membrane and causing cell membrane depolarization. This novel mechanism of action may contribute to telavancin's rapid bactericidal activity and its improved activity over vancomycin against some antibiotic resistance gram-positive bacteria.

Display Name: Telavancin Hydrochloride

Label: Telavancin Hydrochloride

NCI Thesaurus Code: C87636 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2730005  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
TD-6424
Telavancin Hydrochloride
TELAVANCIN HYDROCHLORIDE
Vancomycin, N(Sup 3'')-(2-(Decylamino)Ethyl)-29-(((Phosphonomethyl)Amino)Methyl)-, Monohydrochloride
Vibativ

External Source Codes: 
CAS Registry Number 560130-42-9 (see NLM ChemIDplus info)
FDA UNII Code 0701472ZG0
PDQ Closed Trial Search ID 698126
PDQ Open Trial Search ID 698126 (check for NCI PDQ open clinical trial info)
UMLS CUI C2730005

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C80H106Cl2N11O27P.HCl
code C87636
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C87636

Mainbox Bottom