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Version: 17.06d (Release date: 2017-06-26)
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Thioguanine (Code C876)

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Terms & Properties

Preferred Name: Thioguanine

Definition: A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called antimetabolites.

Display Name: Thioguanine

Label: Thioguanine

NCI Thesaurus Code: C876 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039902  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Amino-1,7-dihydro-6H-purine-6-thione
2-Amino-6-mercaptopurine
2-Amino-6-purinethiol
2-Aminopurin-6-thiol
2-Aminopurine-6(1H)-thione
2-Aminopurine-6-thiol
2-Amino 6MP
2-Mercapto-6-aminopurine
6-Amino-2-mercaptopurine
6-Mercapto-2-aminopurine
6-Mercaptoguanine
6-TG
6-Thioguanine
6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI)
6 Mercaptoguanine
6 Thioguanine
BW 5071
Lanvis
Tabloid
Thioguanine
thioguanine
THIOGUANINE
Tioguanin
Tioguanine
Wellcome U3B
WR-1141
X 27

External Source Codes: 
CAS Registry Number 154-42-7 (see NLM ChemIDplus info)
CAS Registry Number 5580-03-0 (see NLM ChemIDplus info)
FDA UNII Code FTK8U1GZNX
NSC Code 752 (see NCI DTP info)
PDQ Closed Trial Search ID 43669
PDQ Open Trial Search ID 43669 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039902

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute nonlymphocytic leukemia
Chemical_Formula C5H5N5S.H2O
code C876
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Thioguanine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C876

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