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Version: 17.06d (Release date: 2017-06-26)
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Thiotepa (Code C875)

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Terms & Properties

Preferred Name: Thiotepa

Definition: A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth.

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called alkylating agents.

Display Name: Thiotepa

Label: Thiotepa

NCI Thesaurus Code: C875 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039871  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,1',1"-phosphinothioylidynetrisaziridine
1,1',1''-Phosphinothioyldynetrisaziridine
1,1',1''-Phosphinothioylidynetrisaziridine
Girostan
N,N',N''-triethylenethiophosphoramide
N,N', N''-Triethylenethiophosphoramide
Oncotiotepa
STEPA
Tepadina
TESPA
Tespamin
Tespamine
Thio-Tepa
Thiofosfamide
Thiofozil
Thiophosphamide
Thiophosphoramide
Thioplex
Thiotef
Thiotepa
thiotepa
THIOTEPA
Tifosyl
Tio-tef
TIO TEF
triethylenethiophosphoramide
Triethylenethiophosphoramide
Triethylene thiophosphoramide
Triethylene Thiophosphoramide
Tris(1-aziridinyl)phosphine sulfide
tris(1-aziridinyl)phosphine sulfide
TSPA
WR 45312

External Source Codes: 
CAS Registry Number 52-24-4 (see NLM ChemIDplus info)
FDA UNII Code 905Z5W3GKH
NSC Code 6396 (see NCI DTP info)
PDQ Closed Trial Search ID 42933
PDQ Open Trial Search ID 42933 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039871

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Bladder cancer; Breast cancer; Ovarian cancer; Hodgkins lymphoma; Non-hodgkins lymphoma
Chemical_Formula C6H12N3PS
code C875
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Thiotepa
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C875

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