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Version: 17.06d (Release date: 2017-06-26)
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Thiamine (Code C874)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Thiamine

Definition: A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with antioxidant, erythropoietic, mood modulating, and glucose-regulating activities. Thiamine reacts with adenosine triphosphate (ATP) to form an active coenzyme, thiamine pyrophosphate. Thiamine pyrophosphate is necessary for the actions of pyruvate dehydrogenase and alpha-ketoglutarate in carbohydrate metabolism and for the actions of transketolase, an enzyme that plays an important role in the pentose phosphate pathway. Thiamine plays a key role in intracellular glucose metabolism and may inhibit the action of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine may also protect against lead toxicity by inhibiting lead-induced lipid peroxidation.

NCI-GLOSS Definition: A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Vitamin B1 helps some enzymes work properly, helps break down sugars in the diet, and keeps nerves and the heart healthy. It is found in pork, organ meats, peas, beans, nuts, and whole grains. Vitamin B1 is water-soluble (can dissolve in water) and must be taken in daily. Not enough vitamin B1 can cause a disease called beriberi (a condition marked by heart, nerve, and digestive disorders). Too much vitamin B1 may help cancer cells grow faster.

CRCH Definition: Water-soluble vitamin that is a coenzyme in the metabolism of carbohydrates and branched-chain amino acids. (DRI)

Label: Thiamine

NCI Thesaurus Code: C874 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039840  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B1 Vitamin
Vitamin B1
vitamin B1
Vit B1

External Source Codes: 
CAS Registry Number 59-43-8 (see NLM ChemIDplus info)
ChEBI ID CHEBI:33283 (see ChEBI info)
PDQ Closed Trial Search ID 37856
PDQ Open Trial Search ID 37856 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039840

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C12H17N4OS.Cl
code C874
Contributing_Source CRCH
Contributing_Source FDA
Legacy_Concept_Name Thiamine
Micronutrient Y
Nutrient Y
Semantic_Type Organic Chemical
Semantic_Type Vitamin
Unit mg
US_Recommended_Intake Y

Additional Concept Data: 
Defined Fully by Roles: No  


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