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Version: 17.06d (Release date: 2017-06-26)
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Sodium Selenite (Code C87346)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Sodium Selenite

Definition: An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation.

Display Name: Sodium Selenite

Label: Sodium Selenite

NCI Thesaurus Code: C87346 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0142923  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Disodium Selenium Trioxide
Selenious Acid, Sodium Salt (1:2)
Selenious Acid Disodium Salt
Sodium Selenite
SODIUM SELENITE

External Source Codes: 
CAS Registry Number 10102-18-8 (see NLM ChemIDplus info)
FDA UNII Code HIW548RQ3W
ChEBI ID CHEBI:48843 (see ChEBI info)
PDQ Closed Trial Search ID 681583
PDQ Open Trial Search ID 681583 (check for NCI PDQ open clinical trial info)
UMLS CUI C0142923

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula 2Na.O3Se
code C87346
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C87346

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