skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Thiabendazole (Code C873)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Thiabendazole

Definition: A benzimidazole derivative with anthelminthic property. Although the mechanism of action has not been fully elucidated, thiabendazole inhibits the helminth-specific mitochondrial enzyme fumarate reductase, thereby inhibiting the citric acid cycle, mitochondrial respiration and subsequent production of ATP, ultimately leading to helminth's death. In addition, it has been suggested that thiabendazole may lead to inhibition of microtubule polymerization by binding to beta-tubulin and has an overt ovicidal effect with regard to some trichostrongylids.

Label: Thiabendazole

NCI Thesaurus Code: C873 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039832  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Mintezol
MK-360
MK 360
TBZ
THIABENDAZOLE
Thiabendazole
Thibenzole

External Source Codes: 
CAS Registry Number 148-79-8 (see NLM ChemIDplus info)
FDA UNII Code N1Q45E87DT
ChEBI ID CHEBI:45979 (see ChEBI info)
NSC Code 90507 (see NCI DTP info)
PDQ Closed Trial Search ID 39713
PDQ Open Trial Search ID 39713 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039832

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H7N3S
code C873
Contributing_Source FDA
Legacy_Concept_Name Thiabendazole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C873

Mainbox Bottom