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Version: 17.06d (Release date: 2017-06-26)
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Dienogest (Code C87238)

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Terms & Properties

Preferred Name: Dienogest

Definition: An orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therapy and as a female contraceptive. Upon oral administration, dienogest binds intracellular progesterone receptors which then translocate to the nucleus where the drug-receptor complex interacts with progesterone response elements, thus altering the expression of target genes. Dienogest reduces the production of estradiol, prevents ovulation and alters the cervical mucus and endometrium. In addition, dienogest appears to suppress the expression of cell cycle regulator cyclin D1. Altogether, this may prevent the growth of endometrial epithelial cells and may reduce symptoms associated with leiomyoma.

Label: Dienogest

NCI Thesaurus Code: C87238 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0057916  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
19-Norpregna-4,9-Diene-21-Nitrile, 17-Hydroxy-3-Oxo-, (17Alpha)-
M 18575
STS 557
ZK 37659

External Source Codes: 
CAS Registry Number 65928-58-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 743773
PDQ Open Trial Search ID 743773 (check for NCI PDQ open clinical trial info)
UMLS CUI C0057916

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H25NO2
code C87238
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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