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Version: 17.06d (Release date: 2017-06-26)
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Peretinoin (Code C87202)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Peretinoin

Definition: An orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells.

Label: Peretinoin

NCI Thesaurus Code: C87202 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1453741  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2E,4E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,4,6,10,14-Pentaenoic Acid
NIK-333
Peretinoin
PERETINOIN

External Source Codes: 
CAS Registry Number 81485-25-8 (see NLM ChemIDplus info)
FDA UNII Code 11ALM7A4RV
PDQ Closed Trial Search ID 737371
PDQ Open Trial Search ID 737371 (check for NCI PDQ open clinical trial info)
UMLS CUI C1453741

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H30O2
code C87202
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C87202

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