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Version: 17.06d (Release date: 2017-06-26)
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Theophylline (Code C872)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Theophylline

Definition: A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Physiologically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm. (NCI04)

NCI-GLOSS Definition: A drug used to improve breathing in people who are short of breath. It belongs to the family of drugs called bronchodilators or respiratory smooth muscle relaxants.

Display Name: Theophylline

Label: Theophylline

NCI Thesaurus Code: C872 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039771  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,3-Dimethylxanthine Monohydrate
3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione Monohydrate
Constant-T
Elixophyllin
LaBID
Respbid
Slo-bid
Slo-Phyllin
Somophyllin-CRT
Somophyllin-T
T-Phyl
Theo-24
Theobid Duracap
Theochron
Theophylline
THEOPHYLLINE
theophylline
Theophylline Monohydrate
Uniphyl

External Source Codes: 
CAS Registry Number 5967-84-0 (see NLM ChemIDplus info)
FDA UNII Code C137DTR5RG
NSC Code 2066 (see NCI DTP info)
PDQ Closed Trial Search ID 41340
PDQ Open Trial Search ID 41340 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039771

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C7H8N4O2.H2O
code C872
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Theophylline
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C872

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