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Version: 17.06d (Release date: 2017-06-26)
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Thalidomide (Code C870)

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Terms & Properties

Preferred Name: Thalidomide

Definition: A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis.

NCI-GLOSS Definition: A drug that is used to treat multiple myeloma in patients who have just been diagnosed, and a painful skin disease related to leprosy. It is also being studied in the treatment of other types of cancer. Thalomid belongs to the family of drugs called angiogenesis inhibitors.

Display Name: Thalidomide

Label: Thalidomide

NCI Thesaurus Code: C870 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039736  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+)-Thalidomide
(-)-Thalidomide
.alpha.-Phthalimidoglutarimide
2,6-Dioxo-3-phthalimidopiperidine
2, 6-Dioxo-3-phthalimidopiperidine
2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
3-Phthalimidoglutarimide
Alpha-Phthalimidoglutarimide
Contergan
Distaval
Kevadon
N-(2,6-Dioxo-3-piperidyl)phthalimide
N-Phthaloylglutamimide
N-Phthalylglutamic acid imide
N-Phthalylglutamic Acid Imide
Neurosedyn
Pantosediv
Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (+)-
Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (-)-
Sedalis
Sedoval K-17
Softenon
Synovir
Talimol
Thalidomide
THALIDOMIDE
thalidomide
Thalomid

External Source Codes: 
CAS Registry Number 50-35-1 (see NLM ChemIDplus info)
FDA UNII Code 4Z8R6ORS6L
ChEBI ID CHEBI:9513 (see ChEBI info)
NSC Code 66847 (see NCI DTP info)
PDQ Closed Trial Search ID 42332
PDQ Open Trial Search ID 42332 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039736

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Aphthous stomatitis; Crohns disease; cutaneous manifestations of erythema nodosum leprosum; GVHD; HIV-associated wasting syndrome; Karposi sarcoma; lepromatous leprosy; multiple myeloma; mycobacterium tuberculosis and nontuberculosis; primary brain tumors
Chemical_Formula C13H10N2O4
code C870
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Thalidomide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C870

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