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Version: 17.06d (Release date: 2017-06-26)
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Tetrahydrouridine (Code C868)

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Terms & Properties

Preferred Name: Tetrahydrouridine

Definition: A synthetic pyrimidine nucleoside analogue with biomodulating activity. Tetrahydrouridine increases the efficacy of the radiosensitizer cytochlor (5-chloro-2'-deoxycytidine) by inhibiting the enzyme deoxycytidine monophosphate (dCMP) deaminase and preventing the premature deamination of the cytochlor metabolite 5-chloro-2'-deoxycytidine monophosphate (CldCMP) to 5-chloro-2'-deoxyuridine monophosphate (CldUMP); in turn, this increases tumor concentrations of CldUMP which is then further anabolized and incorporated selectively into tumor DNA as CldU (5-chloro-2'-deoxyuridine). (NCI04)

NCI-GLOSS Definition: A substance that makes tumor cells more sensitive to radiation therapy and is being studied in the treatment of cancer. It belongs to the families of drugs called cytidine deaminase inhibitors, multidrug resistance modulators, and radiosensitizers.

Display Name: Tetrahydrouridine

Label: Tetrahydrouridine

NCI Thesaurus Code: C868 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039677  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-
Tetrahydrouridine
tetrahydrouridine
THU

External Source Codes: 
CAS Registry Number 18771-50-1 (see NLM ChemIDplus info)
NSC Code 112907 (see NCI DTP info)
PDQ Closed Trial Search ID 39710
PDQ Open Trial Search ID 39710 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039677

Other Properties:
     Name Value (qualifiers indented underneath)
code C868
Contributing_Source CTRP
Legacy_Concept_Name Tetrahydrouridine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C868

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