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Version: 17.06d (Release date: 2017-06-26)
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Tetradecanoylphorbol Acetate (Code C866)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Tetradecanoylphorbol Acetate

Definition: A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of leukemias and lymphomas. It is also being studied in the treatment of other types of cancer. Tetradecanoylphorbol acetate affects many cell actions and may cause tumor cells to die. It is a type of phorbol ester.

Display Name: Tetradecanoylphorbol Acetate

Label: Tetradecanoylphorbol Acetate

NCI Thesaurus Code: C866 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039654  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
12-O-tetradecanoylphorbol-13-acetate
Lonomycin
PHORBOL 12-MYRISTATE 13-ACETATE DIESTER
Phorbol Myristate Acetate
PMA
Tetradecanoylphorbol Acetate
tetradecanoylphorbol acetate
TPA
TPA (Phorbol Ester)

External Source Codes: 
CAS Registry Number 16561-29-8 (see NLM ChemIDplus info)
FDA UNII Code NI40JAQ945
ChEBI ID CHEBI:37537 (see ChEBI info)
NSC Code 262244 (see NCI DTP info)
PDQ Closed Trial Search ID 43661
PDQ Open Trial Search ID 43661 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039654

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C36H56O8
code C866
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tetradecanoylphorbol_Acetate
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C866

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