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Version: 17.06d (Release date: 2017-06-26)
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Therapeutic Testosterone (Code C862)

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Terms & Properties

Preferred Name: Therapeutic Testosterone

Definition: A synthetic form of the endogenous androgenic steroid testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization. Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative.

Display Name: Therapeutic Testosterone

Label: Therapeutic Testosterone

NCI Thesaurus Code: C862 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039601  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(17Beta)-17-hydroxyandrost-4-en-3-one
Delta4-Androsten-17beta-ol-3-one
Mertestate
Testoderm
Testolin
TESTOSTERONE
Testosterone
Testostroval
Testostroval-PA
Testro AQ
Therapeutic Testosterone
Trans-Testosterone
Virosterone

External Source Codes: 
CAS Registry Number 58-22-0 (see NLM ChemIDplus info)
FDA UNII Code 3XMK78S47O
ChEBI ID CHEBI:17347 (see ChEBI info)
NSC Code 9700 (see NCI DTP info)
PDQ Closed Trial Search ID 42926
PDQ Open Trial Search ID 42926 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039601

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Delayed puberty, male; Hypogonadism; Metastatic mammary cancer
Chemical_Formula C19H28O2
code C862
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Therapeutic_Testosterone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C862

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