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Version: 17.06d (Release date: 2017-06-26)
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Teniposide (Code C857)

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Terms & Properties

Preferred Name: Teniposide

Definition: A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04)

NCI-GLOSS Definition: An anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors.

Display Name: Teniposide

Label: Teniposide

NCI Thesaurus Code: C857 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039512  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4'-Demethylepipodophyllotoxin-beta-D-thenylidine Glucoside
4'-Demethylepipodophyllotoxin 9-(4,6-O-2-Thenylidene-beta-D-glucopyranoside)
[5R-[5Alpha,5a beta,8a alpha, 9beta(R*)]]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl]oxy]furo[3',4':6,7]-naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Thenylidene Lignan
VM 26

External Source Codes: 
CAS Registry Number 29767-20-2 (see NLM ChemIDplus info)
FDA UNII Code 957E6438QA
NSC Code 122819 (see NCI DTP info)
PDQ Closed Trial Search ID 43671
PDQ Open Trial Search ID 43671 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039512

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C32H32O13S
code C857
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Teniposide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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