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Version: 17.06d (Release date: 2017-06-26)
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Tamoxifen Citrate (Code C855)

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Terms & Properties

Preferred Name: Tamoxifen Citrate

Definition: The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC.

NCI-GLOSS Definition: A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen citrate is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen citrate is a type of antiestrogen.

Display Name: Tamoxifen Citrate

Label: Tamoxifen Citrate

NCI Thesaurus Code: C855 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0700621  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate
(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene Citrate
Apo-Tamox
Clonoxifen
Dignotamoxi
Ebefen
Emblon
Estroxyn
Fentamox
Gen-Tamoxifen
Genox
ICI-46474
ICI 46,474
Jenoxifen
Kessar
Ledertam
Lesporene
Nolgen
Noltam
Nolvadex
Nolvadex-D
Nourytam
Novo-Tamoxifen
Novofen
Noxitem
Oestrifen
Oncotam
PMS-Tamoxifen
Soltamox
TAM
Tamax
Tamaxin
Tamifen
Tamizam
Tamofen
Tamoxasta
Tamoxifeni Citras
Tamoxifen Citrate
TAMOXIFEN CITRATE
tamoxifen citrate
Tamoxifen citrate
Zemide

External Source Codes: 
CAS Registry Number 54965-24-1 (see NLM ChemIDplus info)
FDA UNII Code 7FRV7310N6
ChEBI ID CHEBI:9397 (see ChEBI info)
NSC Code 180973 (see NCI DTP info)
PDQ Closed Trial Search ID 42901
PDQ Open Trial Search ID 42901 (check for NCI PDQ open clinical trial info)
UMLS CUI C0700621

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast cancer; Endometrial cancer; Gynecomastia; Melanoma; Ovarian cancer
Chemical_Formula C26H29NO.C6H8O7
code C855
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tamoxifen
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C855

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