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Version: 16.10e (Release date: 2016-10-31)
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Buprenorphine Transdermal Matrix Patch (Code C85483)

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Terms & Properties

Preferred Name: Buprenorphine Transdermal Matrix Patch

Definition: A transdermal matrix patch containing the synthetic opioid buprenorphine with analgesic and sedative activities. Buprenorphine binds to and activates the mu-opioid receptors in the central nervous system (CNS), thereby mimicking the effects of the endogenous opiates. Binding to opioid receptors stimulates exchange of GTP for GDP, inhibits adenylate cyclase, and decreases intracellular cAMP. This inhibits the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In addition, buprenorphine closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels, resulting in hyperpolarization, reduced neuronal excitability, analgesia and sedation. Buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor in the CNS.

Display Name: Buprenorphine Transdermal Matrix Patch

Label: Buprenorphine Transdermal Matrix Patch

NCI Thesaurus Code: C85483 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412371  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Buprenorphine Transdermal Matrix Patch
Transdermal Buprenorphine

External Source Codes: 
PDQ Closed Trial Search ID 648124
PDQ Open Trial Search ID 648124 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412371

Other Properties:
Name Value (qualifiers indented underneath)
code C85483
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C85483

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