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Version: 16.11d (Release date: 2016-11-28)
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2-Hydroxyflutamide Depot (Code C85482)

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Terms & Properties

Preferred Name: 2-Hydroxyflutamide Depot

Definition: A depot formulation containing a bioresorbable, controlled-release, calcium sulphate-based paste of the nonsteroidal antiandrogen 2-hydroxyflutamide (2-HOF) with potential antineoplastic activity. Upon injection into the tumor site in the prostate, 2-hydroxyflutamide depot slowly releases 2-HOF, which competitively binds to androgen receptors (ARs), blocking the binding of dihydrotestosterone (DHT). This may inhibit androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest and decreased cellular proliferation. In addition, 2-HOF inhibits nuclear uptake of androgen in androgen-responsive tissues.

Label: 2-Hydroxyflutamide Depot

NCI Thesaurus Code: C85482 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412370  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Hydroxyflutamide Controlled-Release Formulation
2-Hydroxyflutamide Depot
Liproca

External Source Codes: 
PDQ Closed Trial Search ID 648122
PDQ Open Trial Search ID 648122 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412370

Other Properties:
Name Value (qualifiers indented underneath)
code C85482
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C85482

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