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National Cancer Institute
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Version: 16.09d (Release date: 2016-09-26)
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Multikinase Inhibitor ARRY614 (Code C85481)

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Terms & Properties

Preferred Name: Multikinase Inhibitor ARRY614

Definition: An orally bioavailable small-molecule inhibitor of p38 and Tie2 kinases with potential antineoplastic, anti-inflammatory and antiangiogenic activities. p38/Tie2 kinase inhibitor Arry-614 binds to and inhibits the activities of p38 and Tie2 kinases, which may inhibit the production of proinflammatory cytokines and may decrease tumor angiogenesis and tumor cell growth and survival. p38 is a MAP kinase that is often upregulated in cancer cells, playing a crucial part in the production of a variety of cytokines involved in inflammation and cellular proliferation such as tumor necrosis factor (TNF) and interleukin (IL)-1 and -6. Tie2 is an endothelial cell specific receptor that is activated by angiopoietins, growth factors required for angiogenesis. This agent has also been reported to inhibit other kinases including vascular endothelial growth factor receptor (VEGFR2) and Src tyrosine kinases.

Display Name: Multikinase Inhibitor ARRY614

Label: Multikinase Inhibitor ARRY614

NCI Thesaurus Code: C85481 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412366  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Multikinase Inhibitor ARRY614

External Source Codes: 
PDQ Closed Trial Search ID 647828
PDQ Open Trial Search ID 647828 (check for NCI PDQ open clinical trial info)

Other Properties:
Name Value (qualifiers indented underneath)
code C85481
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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