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Version: 16.11d (Release date: 2016-11-28)
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Ferumoxides Injectable Solution (Code C85477)

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Terms & Properties

Preferred Name: Ferumoxides Injectable Solution

Definition: An injectable, aqueous colloid solution containing a non-stoichiometric magnetite core of superparamagnetic iron oxide (SPIO) coated with dextran administered as a magnetic resonance imaging (MRI) contrast media. Upon intravenous administration, ferumoxides accumulates in phagocytic reticuloendothelial system (RES) cells of the liver (Kupffer cells). When exposed to a strong external magnetic field, ferumoxides exhibits enhanced T2 relaxation, resulting in signal loss in normal tissues (image darkening) on mid T1/T2 or strongly T2-weighted images. Tissues with decreased RES function such as metastases, primary liver cancer, cysts and various benign tumors, adenomas, and hyperplasia, retain their native signal intensity, consequently the contrast between normal tissue (with image darkening) and abnormal tissue is increased.

Label: Ferumoxides Injectable Solution

NCI Thesaurus Code: C85477 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1250871  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Feridex
Ferumoxides Injectable Solution

External Source Codes: 
PDQ Closed Trial Search ID 647806
PDQ Open Trial Search ID 647806 (check for NCI PDQ open clinical trial info)
UMLS CUI C1250871

Other Properties:
Name Value (qualifiers indented underneath)
code C85477
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C85477

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