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Version: 17.12d (Release date: 2017-12-26)
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Micellar Nanoparticle-Encapsulated Cisplatin NC-6004 (Code C85476)

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Terms & Properties

Preferred Name: Micellar Nanoparticle-Encapsulated Cisplatin NC-6004

Definition: A nanoparticle-based prodrug formulation consisting of polymeric micelles incorporating the inorganic platinum agent cisplatin with potential antineoplastic activity. In micellar nanoparticle-encapsulated cisplatin NC-6004, cisplatin forms a polymer-metal complex with hydrophilic polyethylene glycol poly(glutamic acid) block copolymers by attaching to the micelle inner core consisting of the hydrophobic polyamino acids. Upon cell entry and release from the polymer-metal complex, cisplatin forms highly reactive, charged platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-linking, DNA-protein cross-linking and, subsequently, tumor cell apoptosis and growth inhibition. Due to the hydrophilic nature of polyethylene glycol, this formulation increases the water-solubility of cisplatin and decreases the nephrotoxicity and neurotoxicity associated with the administration of cisplatin alone.

Label: Micellar Nanoparticle-Encapsulated Cisplatin NC-6004

NCI Thesaurus Code: C85476 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830141  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Micellar Nanoparticle-Encapsulated Cisplatin NC-6004

External Source Codes: 
PDQ Closed Trial Search ID 647541
PDQ Open Trial Search ID 647541 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830141

Other Properties:
     Name Value (qualifiers indented underneath)
code C85476
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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