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Version: 17.06d (Release date: 2017-06-26)
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Carbon C 14 Eribulin Acetate (Code C85472)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Carbon C 14 Eribulin Acetate

Definition: A radioconjugate containing the acetate salt of eribulin, labeled with the beta particle-emitting radioisotope carbon C 14, with radioisotopic and potential antineoplastic activities. Upon administration, eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. The radioisotope moiety of this agent acts as a radioactive tracer.

Label: Carbon C 14 Eribulin Acetate

NCI Thesaurus Code: C85472 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412350  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
14C-Eribulin Acetate
Carbon C 14 Eribulin Acetate

External Source Codes: 
PDQ Closed Trial Search ID 646836
PDQ Open Trial Search ID 646836 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412350

Other Properties:
     Name Value (qualifiers indented underneath)
code C85472
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C85472

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