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Version: 17.06d (Release date: 2017-06-26)
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pan-PI3K/mTOR Inhibitor SF1126 (Code C85469)

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Terms & Properties

Preferred Name: pan-PI3K/mTOR Inhibitor SF1126

Definition: A water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival.

Display Name: pan-PI3K/mTOR Inhibitor SF1126

Label: pan-PI3K/mTOR Inhibitor SF1126

NCI Thesaurus Code: C85469 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2351370  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
pan-PI3K/mTOR Inhibitor SF1126

External Source Codes: 
PDQ Closed Trial Search ID 644818
PDQ Open Trial Search ID 644818 (check for NCI PDQ open clinical trial info)
UMLS CUI C2351370

Other Properties:
     Name Value (qualifiers indented underneath)
code C85469
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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