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Version: 17.06d (Release date: 2017-06-26)
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Silmitasertib Sodium (Code C85460)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Silmitasertib Sodium

Definition: The sodium salt of silmitasertib, an orally bioavailable small-molecule inhibitor of CK2 with potential antineoplastic activity. Silmitasertib selectively binds to and inhibits the enzyme casein kinase II (CK2), which may lead to an inhibition of cellular proliferation. CK2, a protein kinase often overexpressed in a variety of cancer cell types, appears to be correlated with malignant transformation, tumor growth and survival.

Display Name: Silmitasertib Sodium

Label: Silmitasertib Sodium

NCI Thesaurus Code: C85460 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830136  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-((3-chlorophenyl)amino)-benzo(c)-2,6-naphthyridine-8-carboxylic Acid Sodium Salt
CK2 Inhibitor CX-4945
CX-4945
Silmitasertib Sodium
SILMITASERTIB SODIUM

External Source Codes: 
CAS Registry Number 1009820-21-6 (see NLM ChemIDplus info)
FDA UNII Code N1E607PU86
PDQ Closed Trial Search ID 643477
PDQ Open Trial Search ID 643477 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830136

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H11ClN3O2.Na
code C85460
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C85460

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