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Version: 17.06d (Release date: 2017-06-26)
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Technetium Tc-99m-NC100692 (Code C85458)

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Terms & Properties

Preferred Name: Technetium Tc-99m-NC100692

Definition: A synthetic Arg-Gly-Asp (RGD)-containing cyclic peptide radiolabeled with technetium Tc 99m with integrin-binding and radioisotopic activities. Upon administration, technectium Tc 99m-NC100692 binds to alpha5beta3 integrin and to a lesser extent alpha5beta5; subsequently, alpha5beta3-expressing tumor cells can be visualized using scintigraphy and the degree of tumor angiogenesis can be determined. Integrins, membrane-spanning protein receptors, may be upregulated on proliferating endothelial cells; their overexpression has been associated with neovascularization, differentiation, proliferation of tumor cells and poor prognosis.

Label: Technetium Tc-99m-NC100692

NCI Thesaurus Code: C85458 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412329  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Tc-99m-NC100692
Technetium Tc-99m-NC100692

External Source Codes: 
PDQ Closed Trial Search ID 643465
PDQ Open Trial Search ID 643465 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412329

Other Properties:
     Name Value (qualifiers indented underneath)
code C85458
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C85458

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