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Version: 17.06d (Release date: 2017-06-26)
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Vinorelbine Tartrate Oral (Code C85457)

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Terms & Properties

Preferred Name: Vinorelbine Tartrate Oral

Definition: An orally bioavailable tartrate salt of vinorelbine, a semisynthetic vinca alkaloid with potential antineoplastic activity. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent.

Label: Vinorelbine Tartrate Oral

NCI Thesaurus Code: C85457 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412328  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Navelbine
Vinorelbine Tartrate Oral

External Source Codes: 
PDQ Closed Trial Search ID 642976
PDQ Open Trial Search ID 642976 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412328

Other Properties:
     Name Value (qualifiers indented underneath)
code C85457
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C85457

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