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Version: 16.10e (Release date: 2016-10-31)
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Onalespib (Code C85454)

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Terms & Properties

Preferred Name: Onalespib

Definition: A synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins.

Display Name: Onalespib

Label: Onalespib

NCI Thesaurus Code: C85454 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2830135  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2,4-Dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone
AT-13387
AT13387
AT 13387
Onalespib
ONALESPIB

External Source Codes: 
CAS Registry Number 912999-49-6 (see NLM ChemIDplus info)
FDA UNII Code Q7Y33N57ZZ
PDQ Closed Trial Search ID 642817
PDQ Open Trial Search ID 642817 (check for NCI PDQ open clinical trial info)
UMLS CUI C2830135

Other Properties:
Name Value (qualifiers indented underneath)
code C85454
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C85454

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