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Version: 16.11d (Release date: 2016-11-28)
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Fluorine F 18-VM4-037 (Code C85449)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluorine F 18-VM4-037

Definition: A radiopharmaceutical consisting of a sulfonamide covalently attached to the positron-emitting isotope fluorine F 18 with CA-IX-binding and radioisotopic activities. Upon administration, the sulfonamide moiety of [F18]VM4-037 binds to the cell-surface tumor-associated antigen (TAA) carbonic anhydrase IX isoenzyme (CA-IX); CA-IX-expressing tumor cells can then be visualized using positron emission tomography (PET). CA-IX has been found to be elevated in a variety of hypoxic tumors; elevated CA-IX has been positively correlated with tumor growth, tumor invasion and poor prognosis.

Display Name: Fluorine F 18-VM4-037

Label: Fluorine F 18-VM4-037

NCI Thesaurus Code: C85449 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412318  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[F18]VM4-037
Fluorine F 18-VM4-037

External Source Codes: 
PDQ Closed Trial Search ID 642612
PDQ Open Trial Search ID 642612 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412318

Other Properties:
Name Value (qualifiers indented underneath)
code C85449
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C85449

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