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Version: 17.06d (Release date: 2017-06-26)
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Akt Inhibitor SR13668 (Code C85448)

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Terms & Properties

Preferred Name: Akt Inhibitor SR13668

Definition: An orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities. Akt inhibitor SR13668 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation, and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Display Name: Akt Inhibitor SR13668

Label: Akt Inhibitor SR13668

NCI Thesaurus Code: C85448 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412317  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Akt Inhibitor SR13668
SRI13668

External Source Codes: 
PDQ Closed Trial Search ID 642606
PDQ Open Trial Search ID 642606 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412317

Other Properties:
     Name Value (qualifiers indented underneath)
code C85448
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C85448

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