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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Human Angiotensin Converting Enzyme 2 APN01 (Code C85447)

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Terms & Properties

Preferred Name: Recombinant Human Angiotensin Converting Enzyme 2 APN01

Definition: A recombinant, soluble glycosylated form of human angiotensin converting enzyme 2 (rhACE2) with antihypertensive and potential antineoplastic activities. Recombinant human angiotensin converting enzyme 2 APN01 may normalize ACE2 levels, cleaving angiotensin II to create angiotensin-(1-7) and restoring the function of the renin-angiotensin system (RAS). ACE2, a homolog of ACE1, appears to function as a negative regulator of the RAS system by converting angiotensin II to angiotensin-(1-7), a peptide with actions that counteract the cardiovascular actions of angiotensin II. In addition, angiotensin-(1-7) may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) G protein-coupled receptor Mas, resulting in diminished tumor cell proliferation. ACE2 levels may be reduced in malignancy and diabetes and in liver, cardiovascular and lung diseases.

Label: Recombinant Human Angiotensin Converting Enzyme 2 APN01

NCI Thesaurus Code: C85447 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL412316  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
APN01
Recombinant Human Angiotensin Converting Enzyme 2 APN01
rhACE2 APN01

External Source Codes: 
PDQ Closed Trial Search ID 642531
PDQ Open Trial Search ID 642531 (check for NCI PDQ open clinical trial info)
NCI META CUI CL412316

Other Properties:
     Name Value (qualifiers indented underneath)
code C85447
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C85447

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