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Version: 17.06d (Release date: 2017-06-26)
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Tivozanib (Code C85444)

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Terms & Properties

Preferred Name: Tivozanib

Definition: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.

Display Name: Tivozanib

Label: Tivozanib

NCI Thesaurus Code: C85444 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2827667  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-

External Source Codes: 
CAS Registry Number 475108-18-0 (see NLM ChemIDplus info)
FDA UNII Code 172030934T
PDQ Closed Trial Search ID 561728
PDQ Open Trial Search ID 561728 (check for NCI PDQ open clinical trial info)
UMLS CUI C2827667

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H19ClN4O5
code C85444
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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