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National Cancer Institute
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Version: 17.07e (Release date: 2017-07-31)
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Suramin (Code C853)

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Terms & Properties

Preferred Name: Suramin

Definition: A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04)

NCI-GLOSS Definition: A drug that is used to treat infections caused by parasites. It is also being studied in the treatment of cancer. It belongs to the families of drugs called antiprotozoals and anthelmintics.

Display Name: Suramin

Label: Suramin

NCI Thesaurus Code: C853 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0038880  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 145-63-1 (see NLM ChemIDplus info)
FDA UNII Code 6032D45BEM
ChEBI ID CHEBI:45906 (see ChEBI info)
PDQ Closed Trial Search ID 40052
PDQ Open Trial Search ID 40052 (check for NCI PDQ open clinical trial info)
UMLS CUI C0038880

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Trypanosomiasis; hormone-refractory prostate cancer
Chemical_Formula C51H40N6O23S6
code C853
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Suramin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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