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Version: 17.06d (Release date: 2017-06-26)
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Sulindac (Code C850)

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Terms & Properties

Preferred Name: Sulindac

Definition: A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)

NCI-GLOSS Definition: A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer.

Display Name: Sulindac

Label: Sulindac

NCI Thesaurus Code: C850 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0038792  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
Aflodac
Algocetil
Apo-Sulin
Arthrocine
Artribid
cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
Citireuma
Clinoril
Clisundac
Imbaral
MK-231
Novo-Sundac
Reumofil
Reumyl
Sudac
Sulindac
sulindac
SULINDAC
Sulindac Sulfoxide
Sulinol
Sulreuma

External Source Codes: 
CAS Registry Number 38194-50-2 (see NLM ChemIDplus info)
FDA UNII Code 184SNS8VUH
ChEBI ID CHEBI:9352 (see ChEBI info)
PDQ Closed Trial Search ID 41538
PDQ Open Trial Search ID 41538 (check for NCI PDQ open clinical trial info)
UMLS CUI C0038792

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Arthritis; inflammatory conditions
Chemical_Formula C20H17FO3S
code C850
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Sulindac
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C850

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